Bcl-2 is a member of a family of proteins that are involved in apoptosis. Bcl-2 is an integral inner mitochondrial membrane protein of 25 kD and has a wide tissue distribution. It is considered to act as an inhibitor of apoptosis. For this reason, bcl-2 expression is inhibited in germinal centers where apoptosis forms part of the B cell production pathway.
In 90% of follicular lymphomas a translocation occurs which juxtaposes the bcl-2 gene at 18q21, to an immunoglobulin gene. This t(14;18) translocation can deregulate gene expression and bcl-2 over-expression can be demonstrated immunohistochemically in the vast majority of follicular lymphomas.
| Item Number | Description | |||||
|---|---|---|---|---|---|---|
| PA0117 | Bcl-2 Oncoprotein (bcl-2/100/D5), 7 ml | Bond Ready-to-Use Primary Antibody, CE/IVD | Details | Request Offer | ||
| Item Number | Description | ||||
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| Item Number | Description | ||||
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| name | Type | ||
|---|---|---|---|
| PAXXXX_D_FR_EN_IT | MSDS | Download | |
| PA0117-BP | Datasheet | Download | |
